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WEBSITE TERMS OF USE AGREEMENT

Thank you for visiting the Web Site of PTC Therapeutics, Inc. (the “Company”). The Company grants you the right to use this Web Site subject to the terms and conditions of use set forth below (this “Terms of Use Agreement”).

IMPORTANT NOTICE: The information provided on this Web Site is for general informational and educational purposes only. This website may provide information about medical conditions and their treatment. PTC makes no representation that material on this site is appropriate or available for use outside of the United States of America. Individuals that choose to access this site from other locations do so on their own initiative and are responsible for compliance with local laws if and to the extent that local laws are applicable. Please read and review this Terms of Use Agreement carefully before accessing or using this Web Site. By accessing or using this site, you acknowledge that you have read, understood and agreed to this Terms of Use Agreement. If you do not agree to this Terms of Use Agreement, you may not access or use the site.

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Void Where Prohibited. This Web Site and its content are intended to comply with the laws and regulations in the U.S. Although the information on this Web Site is accessible to users outside of the U.S., the information pertaining to the Company’s products is intended for use only by residents of the U.S. Other countries may have laws, regulatory requirements and medical practices that differ from those in the U.S. This site links to other sites produced by the Company’s various operating divisions and subsidiaries, some of which are outside the U.S. Those sites may have information that is appropriate only to that particular originating country. The Company reserves the right to limit provision of its products or services to any person, geographic region or jurisdiction and/or to limit the quantities or any products or services it provides. Any offer for any product or service made on this Web Site is void where prohibited.

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Miscellaneous. If any provision of this Agreement is held to be unlawful, void or unenforceable, then such provision shall be severable without affecting the enforceability of all remaining provisions. The Company reserves the right to alter or delete materials from this Web Site at any time at its discretion.

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Date of preparation: September 2022
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Important Terms and Concepts

Basic terms and key definitions

Neuromuscular disorders

Neuromuscular disorders affect the muscles and nerves, and most of the causes are genetic. This means they are either passed down through the family or caused by changes in an individual person’s genes.

Most neuromuscular disorders cause muscle weakness that worsens over time. Signs and symptoms of neuromuscular diseases can vary and may be mild, moderate, or severe.

Most often, when a child has a neuromuscular disease, they don’t grow and develop as fast as other children their age. They are often slow to start lifting their head, sitting, walking, and talking.

Treatment and supportive care may improve the symptoms of a neuromuscular disorder, increasing mobility and even life expectancy.

Muscular dystrophy

Muscular dystrophy is the term for a group of neuromuscular disorders that cause muscle weakness and muscle loss.

Duchenne muscular dystrophy (DMD) is a type of muscular dystrophy that causes muscle weakness that worsens over time. The progression and symptoms can vary from person to person.